PMBL in prevention of Respiratory infections in Children
The clinical trial performed by Aksic demonstrated a significant reduction of number of infections in children treated with PMBL (-54%) as compared to the placebo and as well a reduction of the school absenteism (-49.7%).
Number of episodes of infections
Evaluation of the clinical efficacy of a new polyvalent bacterial lysate obtained by mechanical lysis (PMBL) in a population of 180 school- aged children with recurrent respiratory infections.
2005, M. Aksic & al.
- RCT with one comparative arm to chemical lysate
- Study duration: 7 months
- 180 children aged from 5 to 10 with at least 4 episodes last year, randomized in 2 groups
- Treatment regiment: daily administration of Ismigen for 10 consecutive days X3 months
- 3 months up treatment, 4 months follow up