Expertise

Lallemand is one of the world’s leading developer and producer of yeast and bacteria for specialized applications, mainly for the human and animal nutrition and health industries.

Based on its historical expertise in microbiology leveraged by the technological know-how in the industrial processing of these micro-organisms, Lallemand has developed a unique immunobiological solution: Polyvalent Mechanical Bacterial Lysates, or PMBL.

One step ahead of traditional bacterial lysates, PMBL combine a broad diversity of pathogenic antigens to well-conserved antigenic structures. Their immunomodulatory potential is backed by a strong body of mechanistic and clinical evidence.

What is PMBL?

Polyvalent Mechanical Bacterial Lysates is a Bacterial Lysates made from a large array of pathogenic bacteria, including all the most commonly occurring pathogens of the upper and lower respiratory tract.
- Staphylococcus aureus
- Streptococcus viridans
- Streptococcus pneumoniae (six different strains)
- Streptococcus pyogenes
- Klebsiella pneumoniae
- Klebsiella ozenae
- Moraxella catarrhalis
- Hemophylus influenzae
PMBL is the only bacterial lysates on the market obtained by mechanical lysis, which ensures optimal preservation of the pathogens’ antigens structure and conformation, thanks to a proprietary process developed by the Company. Mechanical lysates have been shown more effective that chemical lysate to interact with the immune system and elicit an immune reaction.
Finally, PMBL distinguish itself by its mode of administration: formulated as sublingual tablets, it allows direct contact of the antigens with the mucosal immunocytes of the mouth and the pharynx, while preventing gastric digestion and biliary acids attacks of the antigenic proteins. The sublingual route of administration also offers better protection.

These specificities make of Polyvalent Mechanical Bacterial Lysates effective and polyvalent immunobiological solutions: it does not act only as an oral vaccines against bacterial infections, but also a potential treatment for chronic or acute bacterial or viral infection of the upper and lower respiratory tract.